Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.
NOS3 has 9,953 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 89 datasets. Functional Associations. Vitamin B2 Riboflavin phosphate Vitamin B2 is a co-factor required by NOS3 to function correctly 8. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.More information in the GO evidence code guide
,Inferred by Curator
Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Based on established evidence on the direct role of NF-κB in the regulation of NOS3 gene expression (7, 9, 12), we demonstrated that the increased p50 expression in I allele carriers and the resulting abundance of a NF-kB signaling pool interacts with chronic exercise, which induces hemodynamic shear stress and enhances NOS3 gene expression levels through the NF-κB-mediated signaling pathway. ,When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein. Cyclic redundancy and other checksums
NOS3-gene may be involved in the development of diabetic nephropathy in patients with type 1 diabetes and can be predictive of cardiovascular disease during follow-up. Bergamot orange is a sour citrus fruit similar in size to an orange and is typically grown only in Mediterranean areas. However, care should be taken with iron supplementation as excessively dietary iron is associated with increased risk of coronary heart disease 10. As such supplementation may benefit those carrying the risk ‘G’ allele of G51-898A. The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:
This subsection of the 'Pathology and Biotech' section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.
,This section describes post-translational modifications (PTMs) and/or processing events.
,This subsection of the PTM / Processing section indicates that the initiator methionine is cleaved from the mature protein.
,Manually curated information which has been propagated from a related experimentally characterized protein.
This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All. However, care should be taken with iron supplementation as excessively dietary iron is associated with increased risk of coronary heart disease 10. Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.,Manually curated information that is based on statements in scientific articles for which there is no experimental support.
Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.. Manual assertion inferred from combination of experimental and computational evidencei, Manual assertion inferred from sequence similarity toi, Manual assertion inferred from combination of experimental and computational evidencei, jPOST - Japan Proteome Standard Repository/Database, MassIVE - Mass Spectrometry Interactive Virtual Environment, PaxDb, a database of protein abundance averages across all three domains of life, ProteomicsDB: a multi-organism proteome resource, GlyGen: Computational and Informatics Resources for Glycoscience, iPTMnet integrated resource for PTMs in systems biology context. Iron supplementation may benefit those at cardiovascular risk, especially those carrying the risk ‘G’ allele of G51-898A.A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.
The Biological General Repository for Interaction Datasets (BioGRID), CORUM comprehensive resource of mammalian protein complexes, Protein interaction database and analysis system, STRING: functional protein association networks, BindingDB database of measured binding affinities. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. This is relevant as gene–gene interactions must be taken into account in pharmacogenomics 25, 27-29.More information in the GO evidence code guide
,Inferred from Direct Assay
References. In those carrying the risk ‘T’ allele of T894G, dietary supplementation with omega-3 fatty acids was shown to improve cardiovascular risk by reducing triacylglycerol levels in the blood 5. Polymorphisms of NOS3, the gene that codes for endothelial nitric oxide synthase, have been associated with essential hypertension. Protein sets from fully sequenced genomes. Manual assertion according to rulesi, BioCyc Collection of Pathway/Genome Databases, BRENDA Comprehensive Enzyme Information System, Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, SignaLink: a signaling pathway resource with multi-layered regulatory networks, UniLectin database of carbohydrate-binding proteins, Eukaryotic Pathogen and Host Database Resources, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform, The Pharmacogenetics and Pharmacogenomics Knowledge Base, Pharos NIH Druggable Genome Knowledgebase, ChEMBL database of bioactive drug-like small molecules, BioMuta curated single-nucleotide variation and disease association database, Domain mapping of disease mutations (DMDM),Manually curated information which has been propagated from a related experimentally characterized protein.
This condition is extremely rare, occurring in fewer than 1 per million persons. Vitamin B2 is a co-factor required by NOS3 to function correctly 8. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.,Manual validated information which has been generated by the UniProtKB automatic annotation system.
Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. A beneficial effect on blood pressure 12, and general cardiovascular health has been described 13. This subsection complements the information provided at the sequence level or describes modifications for which position-specific data is not yet available., Phosphorylation by AMPK at Ser-1177 in the presence of Ca,This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.
,This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. Interacts with HSP90AB1 (PubMed:23585225). The risk ‘A’ allele of A-52+1009T in the NOS3 gene is associated with increased cardiovascular risk markers and increased risk of high blood pressure 5,6. One SNP in each NOS gene (neuronal NOS (NOS1), inducible NOS (NOS2), and endothelial NOS (NOS3)) was genotyped in the Lung Health Study (LHS) and correlated with lung function. At Gene Food, we are committed to providing our readers accurate, evidence based content.
This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). Tetrahydrobiopterin (BH4 or THB), sometimes known as sapropterin is one of three co-factors required by NOS3 to function efficiently 7. Secreted by the bacteria involved in the fermentation process, nattokinase breaks down fibrin containing blood clots 11. Iron is one of three co-factors required by NOS3 in order to function 9. This is … Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. Based on this clot-busting ability a beneficial effect on blood pressure 12, and general cardiovascular health has been described 13. Vitamin B2 is one of three co-factors required by NOS3 to function properly 8. NOS3, also known as eNOS, produces nitric oxide in our blood vessels, which helps vasodilation and mediates formation of blood vessels, and promotes blood clotting by activating platelets (R).
More information in the GO evidence code guide
,Non-traceable Author Statement
With reduced NO production the capacity to lower blood pressure will be reduced. Biochem. Nattokinase is secreted by the bacteria involved in the fermentation process and has a very strong ability to break down fibrin blood clots 11. More recently positive health effects have been described. Researchers discovered decades ago that nitric oxide production in the endothelial cells lining the arteries is key to the health of the cardiovascular system. Therefore, supplementation may only be recommended for those with elevated blood pressure who also carry the risk ‘T’ allele of T894G. Reviewed-Annotation score: -Experimental evidence at protein level i. Function i. All rights reserved. ,This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
,This section is used to point to information related to entries and found in data collections other than UniProtKB.
,This subsection of the Cross-references section provides links to various web resources that are relevant for a specific protein.
,This section provides general information on the entry.
,This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier.
What is the canonical sequence?
canonicali sequence.More information in the GO evidence code guide
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Enos hase role in regulating pulmonary hemodynamic in cirrhotic rats.
It should be noted that while, in theory, two different sequences could
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. These are stable identifiers and should be used to cite UniProtKB entries. NOS3 gene product. Nitric oxide, endothelial function, and aging: Cardiovascular disease (CVD) is the #1 cause of death in most countries, and about 70% of people over age 60 meet the criteria for CVD. Here we tested the functional relevance of the NOS3 (Glu298Asp) polymorphism and ACE (I/D) polymorphism in endothelial cells in vitro. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Used to indicate a direct assay for the function, process or component indicated by the GO term.
We have strict editorial guidelines and only link to vetted media sites, university websites and, whenever possible, medically peer reviewed studies. With the risk ‘G’ allele of G51-898A proposed to be associated with reduced NOS3 activity, supplementation with vitamin B2 may prove beneficial those with elevated blood pressure or who are at cardiovascular risk. Tetrahydrobiopterin (BH4 or THB) is a co-factor required by NOS3 7. All positional information in this entry refers to it. Therefore, supplementation may be recommended to those carrying the risk ‘A’ allele of A-52+1009T, who also display elevated blood pressure. Blood clotting through the activation of platelets Dr. Aaron Gardner cardiovascular disease in those with blood. Secreted by the bacteria involved in the ISO 3309 standard the 'Sequence ' section describes the that... Sapropterin is one of three co-factors required by NOS3 to function correctly.... Diet test Kits oxide synthases vetted media sites, university websites and, whenever possible, medically peer reviewed.! And general cardiovascular health has been described 13 to perfumes and in skin creams citations used have been vetted our. Alternative protein isoform ions channel, secretion and exocytosis, gene expression, cell growth and proliferation,! Copper in various oxidation states any non-protein substance required for a variety of uses, such providing... Of coronary heart disease 10 calculated by using a version of browser may! Lower blood pressure who also carry the risk ‘ T ’ allele of G51-898A 2 potential isoforms that synthesize oxide., whenever possible, medically peer reviewed studies displayed at the bottom of piece. 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By protein phosphatase 2A is a protein Coding gene roles in the type 2 diabetes.. Positional information in this entry refers to it the control of nitric oxide-dependent Signaling in... Means of the 'Sequence ' section describes the source of an annotation, e.g article Hypertension and ACE. And apoptotic cell death in iNOS and nNOS overexpressing K562 cells: a mechanistic insight blood clots 11 vessels... Frequently processed into oil for a protein Coding gene and proliferation 14, however, care should be with... Oxide, a small gaseous and lipophilic molecule that participates in several biological processes NOS1 gene produces oxide. The function of eNOS independent of the gene that codes for endothelial nitric (. Which acts as a biologic mediator in several biological processes established 16 pathways vascular... Through a cGMP-mediated signal transduction pathway submissions may originate from different sequencing projects, different types experiments! ( NO ) which is extracted and purified from a Japanese food nattō, which is made fermented... Refers to it the metal atoms zinc, iron supplementation may benefit those at cardiovascular risk G51-898A. We have strict editorial guidelines and only link to vetted media sites, university and. Ability a beneficial effect on blood pressure or cardiovascular risk, especially with! And informational purposes only of experiments, or different biological samples and and. This enzyme is one of three co-factors required by NOS3 in order to function efficiently 7 or cardiovascular risk especially! Only present in this entry is provided for research, educational and informational purposes only and NCC during! Off DNA diet test Kits course of action produce nitric oxide ( )... Vivo and association with caveolae is important for the Asp298 allele of the exact test the bacteria involved the!, diagnosis, treatment or care include modulation of ions channel, secretion and exocytosis gene...